The PIGR Polyclonal Antibody (CAB6130) is a valuable tool for researchers studying the polymeric immunoglobulin receptor (PIGR), a protein involved in the transport of polymeric immunoglobulins across epithelial cells. This antibody, generated in rabbits, exhibits high specificity for human samples and is optimized for use in Western blot applications.PIGR plays a crucial role in mucosal immunity by facilitating the transport of immunoglobulins such as IgA across mucosal surfaces, where they can neutralize pathogens and regulate immune responses.
Dysregulation of PIGR function has been implicated in various inflammatory and infectious diseases, making it an attractive target for research in immunology and infectious disease.By targeting PIGR, researchers can gain insight into the mechanisms underlying mucosal immunity and potentially develop novel therapeutic strategies for immune-related disorders. This antibody is a valuable tool for studies investigating the role of PIGR in health and disease, offering reliable and specific detection of PIGR in various cell types and tissues.
Product Name:
PIGR Rabbit Polyclonal Antibody
SKU:
CAB6130
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 460-600 of human PIGR (NP_002635.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
83kDa
Observed MW:
100kDa
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.
Purification Method:
Affinity purification
Gene ID:
5284
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using PIGR Rabbit pAb (CAB6130) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
