PIGK Antibody (PACO52634)
- SKU:
- PACO52634
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
PIGK Antibody (PACO52634)
The Pigk Polyclonal Antibody (PACO52634) is a crucial tool for researchers studying Pigk, a protein associated with various cellular processes, including cell signaling and lipid metabolism. This antibody, raised in rabbits, exhibits high reactivity with pig samples and is validated for use in applications such as Western blotting.Pigk, also known as phosphatidylinositol glycan anchor biosynthesis class K, is involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors, which are crucial for anchoring proteins to the cell membrane.
Dysregulation of Pigk has been implicated in diseases such as cancer and neurological disorders, making it a promising target for therapeutic interventions.By utilizing the Pigk Polyclonal Antibody, researchers can confidently detect and analyze Pigk in various cellular contexts, shedding light on its role in health and disease. This antibody is a valuable tool for investigators in the fields of molecular biology, biochemistry, and cell biology seeking to unravel the intricate functions of Pigk and its implications in human physiology.
| Antibody Name: | PIGK Antibody (PACO52634) |
| Antibody SKU: | PACO52634 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human GPI-anchor transamidase protein (91-293AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate. All lanes: PIGK antibody at 2.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 46, 37 kDa. Observed band size: 46 kDa. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO52634 at dilution of 1:100. |
| Background: | Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. |
| Synonyms: | GPI-anchor transamidase (GPI transamidase) (EC 3) (GPI8 homolog) (hGPI8) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K), PIGK, GPI8 |
| UniProt Protein Function: | PIGK: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.Protein type: Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; EC 3.-.-.-; Protease; Membrane protein, integral; Endoplasmic reticulumChromosomal Location of Human Ortholog: 1p31.1Cellular Component: endoplasmic reticulum membrane; GPI-anchor transamidase complex; membraneMolecular Function: GPI-anchor transamidase activity; protein binding; protein disulfide isomerase activityBiological Process: attachment of GPI anchor to protein |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92643 |
| NCBI GenInfo Identifier: | 22001630 |
| NCBI Gene ID: | 10026 |
| NCBI Accession: | Q92643.2 |
| UniProt Secondary Accession: | Q92643,O14822, Q5TG77, B2R7K3, B4E2M3 |
| UniProt Related Accession: | Q92643 |
| Molecular Weight: | 36,416 Da |
| NCBI Full Name: | GPI-anchor transamidase |
| NCBI Synonym Full Names: | phosphatidylinositol glycan anchor biosynthesis class K |
| NCBI Official Symbol: | PIGKÂ Â |
| NCBI Official Synonym Symbols: | GPI8Â Â |
| NCBI Protein Information: | GPI-anchor transamidase |
| UniProt Protein Name: | GPI-anchor transamidase |
| UniProt Synonym Protein Names: | GPI8 homolog; hGPI8; Phosphatidylinositol-glycan biosynthesis class K protein; PIG-K |
| Protein Family: | |
| UniProt Gene Name: | PIGKÂ Â |
| UniProt Entry Name: | GPI8_HUMAN |
| Antibodies |
| PIGK Antibody (PACO11238) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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