The PIGH Polyclonal Antibody (PACO04587) is a valuable tool for researchers studying the PIGH protein, a vital component of the glycosylphosphatidylinositol (GPI) anchor biosynthesis pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the PIGH protein, this antibody enables the detection and analysis of PIGH in various cell types, making it ideal for research in immunology, cell biology, and genetics.The PIGH protein is essential for the biosynthesis of GPI anchors, which are involved in anchoring proteins to the cell membrane. Dysregulation of the GPI anchor biosynthesis pathway, including mutations in the PIGH gene, has been linked to various diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and other rare genetic disorders.
By studying the role of PIGH in these conditions, researchers can gain insights into disease mechanisms and potentially identify new therapeutic targets for intervention.Overall, the PIGH Polyclonal Antibody (PACO04587) is a valuable tool for investigating the role of the PIGH protein in health and disease. Its high specificity and reactivity make it a reliable option for researchers looking to advance our understanding of GPI anchor biosynthesis and its implications for human health.
Antibody Name:
PIGH Antibody
Antibody SKU:
PACO04587
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human PIG-H.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PIGH; Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; Phosphatidylinositol-glycan biosynthesis class H protein; PIG-H
UniProt Protein Function:
PIGH: Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the PIGH family.Protein type: Transferase; Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; EC 2.4.1.198Chromosomal Location of Human Ortholog: 14q24.1Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complexMolecular Function: catalytic activityBiological Process: GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane; protein modification process
UniProt Protein Details:
NCBI Summary:
This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
