The PIGC Polyclonal Antibody (PACO40050) is a valuable tool for researchers studying the PIGC protein, a key enzyme involved in the biosynthesis of GPI (glycosylphosphatidylinositol) anchors. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PIGC is essential for the proper functioning of GPI anchors, which play a crucial role in anchoring proteins to the cell membrane. Dysregulation of PIGC has been linked to various diseases, including inherited GPI deficiencies and cancer.
By targeting PIGC with this antibody, researchers can effectively detect and analyze the protein in different cell types, aiding in the investigation of cellular processes involving GPI anchors.The PIGC Polyclonal Antibody is a valuable tool for researchers studying GPI anchor biosynthesis and its role in disease pathology. Its high reactivity and specificity make it a reliable choice for immunology and cancer research, providing insights into potential therapeutic targets for various disorders related to GPI anchor dysfunction.
Antibody Name:
PIGC Antibody (PACO40050)
Antibody SKU:
PACO40050
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Phosphatidylinositol N-acetylglucosaminyltransferase subunit C protein (1-50AA)
Immunofluorescent analysis of PC-3 cells using PACO40050 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Synonyms:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class C protein) (PIG-C), PIGC, GPI2
UniProt Protein Function:
PIGC: Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the PIGC family.Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Transferase; Membrane protein, integral; EC 2.4.1.198Chromosomal Location of Human Ortholog: 1q23-q25Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complexMolecular Function: catalytic activityBiological Process: GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane
UniProt Protein Details:
NCBI Summary:
This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]
