The PIEZO1 Polyclonal Antibody (CAB4340) is a valuable tool for researchers studying PIEZO1, a mechanosensitive ion channel involved in various cellular processes, including touch sensation, vascular development, and red blood cell volume regulation. This antibody is raised in rabbits and is highly specific for human samples, making it suitable for Western blot applications. By binding to the PIEZO1 protein, this antibody enables the detection and analysis of PIEZO1 in different cell types, making it ideal for studies in physiology, neuroscience, and cardiovascular research.
In recent years, PIEZO1 has emerged as a key player in the regulation of cellular responses to mechanical stimuli, making it a potential target for therapeutic interventions in conditions such as cardiovascular diseases, chronic pain, and certain types of cancer. By understanding the functions and regulatory mechanisms of PIEZO1, researchers can gain insights into its role in health and disease and develop novel strategies for treating related disorders.
Product Name:
PIEZO1 Rabbit Polyclonal Antibody
SKU:
CAB4340
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2230-2420 of human FAM38A/PIEZO1 (NP_001136336.2).
The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis.
Purification Method:
Affinity purification
Gene ID:
9780
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from MCF7 cells, using FAM38A/PIEZO1 Rabbit pAb (CAB4340) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
