PICALM Rabbit Polyclonal Antibody (CAB10575)
- SKU:
- CAB10575
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PICALM Rabbit Polyclonal Antibody |
SKU: | CAB10575 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 290-460 of human PICALM (NP_001008660.1). |
Sequence: | IKDS TAAS RATT LSNA VSSL ASTG LSLT KVDE REKQ AALE EEQA RLKA LKEQ RLKE LAKK PHTS LTTA ASPV STSA GGIM TAPA IDIF STPS SSNS TSKL PNDL LDLQ QPTF HPSV HPMS TASQ VAST WGGF TPSP VAQP HPSA GLNV DFES VFGN KSTN VIVD SGGF DEL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 |
Synonyms: | LAP; CALM; CLTH; PICALM |
Positive Sample: | U-251MG,HepG2,MCF7,HeLa,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus, clathrin-coated pit, clathrin-coated vesicle. |
Calculated MW: | 71kDa |
Observed MW: | 71kDa |
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 8301 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |