The PIAS3 Polyclonal Antibody (CAB7060) is a valuable tool for researchers studying the PIAS3 protein, a key regulator of immune response and signaling pathways. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PIAS3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in immunology and cancer research.PIAS3, also known as Protein Inhibitor of Activated STAT3, plays a crucial role in modulating the activity of STAT3, a transcription factor involved in various cellular processes including inflammation and cancer development.
By targeting PIAS3, researchers can gain insight into the intricate mechanisms that regulate immune responses and potentially identify new therapeutic targets for diseases such as cancer and autoimmune disorders. The PIAS3 Polyclonal Antibody offers a unique opportunity to explore the functions of this important protein and its implications in disease progression.
Product Name:
PIAS3 Rabbit Polyclonal Antibody
SKU:
CAB7060
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 452-628 of human PIAS3 (NP_006090.2).
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
10401
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from 293F cells, using PIAS3 Rabbit pAb (CAB7060) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
