The PIAS3 Polyclonal Antibody (CAB13394) is a valuable tool for researchers studying the PIAS3 protein, which plays a crucial role in the regulation of various signaling pathways involved in immune response and inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PIAS3, also known as Protein Inhibitor of Activated STAT 3, functions as a negative regulator of STAT signaling by inhibiting the transcriptional activity of STAT proteins. Dysregulation of PIAS3 has been implicated in various diseases, including cancer and autoimmune disorders, highlighting its potential as a therapeutic target.
By detecting and binding specifically to the PIAS3 protein, this antibody enables researchers to study its expression and localization in different cell types, providing insights into its role in immune regulation and disease pathogenesis. Its versatility and reliability make it an essential tool for studies in immunology, cancer research, and other fields where understanding PIAS3 function is key to advancing knowledge and developing new treatments.
Product Name:
PIAS3 Rabbit Polyclonal Antibody
SKU:
CAB13394
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 399-628 of human PIAS3 (NP_006090.2).
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
10401
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using PIAS3 antibody (CAB13394).
