The PIAS2 Rabbit Monoclonal Antibody (CAB5203) is a valuable tool for research involving PIAS2, a protein involved in post-translational modifications and regulation of gene expression. This antibody, generated in rabbits, is highly specific to PIAS2 in human samples and is validated for use in various applications such as Western blot and immunofluorescence.PIAS2, also known as Protein Inhibitor of Activated STAT 2, is a crucial regulator of signal transduction pathways and plays a key role in immune response and inflammation.
Its involvement in pathways related to cancer, viral infection, and immune disorders makes it an attractive target for therapeutic interventions. The PIAS2 Rabbit Monoclonal Antibody allows for precise detection and analysis of PIAS2 protein levels in different cell types, providing valuable insights into its function and potential as a target for drug development in immunology and oncology research.
Product Name:
PIAS2 Rabbit Monoclonal Antibody
SKU:
CAB5203
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PIAS2 (NP_004662.2).
This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.
Purification Method:
Affinity purification
Gene ID:
9063
Clone Number:
ARC1256
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PIAS2 Rabbit mAb (CAB5203) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
