The PIAS1 Rabbit Monoclonal Antibody (CAB4744) is a valuable tool for researchers studying the PIAS1 protein, a key regulator of gene expression and signal transduction pathways. This antibody, produced using advanced monoclonal technology from rabbit cells, exhibits high specificity and sensitivity in detecting PIAS1 in various experimental settings.PIAS1, also known as Protein Inhibitor of Activated STAT 1, is involved in the regulation of transcription factors and is essential for modulating cellular responses to stimuli such as cytokines, growth factors, and stress signals. Dysregulation of PIAS1 has been linked to various diseases including cancer, inflammatory disorders, and neurological conditions.
The PIAS1 Rabbit Monoclonal Antibody is suitable for use in techniques such as Western blotting, immunofluorescence, and immunoprecipitation, enabling researchers to explore the functions and interactions of PIAS1 in different cell types and biological processes. By targeting PIAS1 with this specific and reliable antibody, researchers can gain insights into the molecular mechanisms underlying disease pathology and potentially identify new therapeutic targets for intervention.
Product Name:
PIAS1 Rabbit Monoclonal Antibody
SKU:
CAB4744
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 3-101 of human PIAS1 (O75925).
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8554
Clone Number:
ARC1116
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PIAS1 Rabbit mAb (CAB4744) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
