The PIAS1 Polyclonal Antibody (CAB5729) is a valuable tool for researchers studying PIAS1, a protein involved in the regulation of various biological processes, including gene expression, cell cycle progression, and immune responses. Raised in rabbits, this antibody is highly specific to human PIAS1 and has been validated for use in Western blot applications.PIAS1, also known as Protein Inhibitor of Activated STAT1, plays a key role in modulating the activity of transcription factors and regulating the immune response. Its involvement in signaling pathways related to inflammation, cell growth, and differentiation makes it a target of interest in cancer research and studies on immune system regulation.
By using the PIAS1 Polyclonal Antibody, researchers can detect and analyze PIAS1 protein levels in different cell types, allowing for a better understanding of its function in normal physiological processes and disease states. This antibody is a valuable tool for scientists looking to uncover the role of PIAS1 in various biological pathways and develop targeted therapies for conditions where PIAS1 dysregulation is implicated.
Product Name:
PIAS1 Rabbit Polyclonal Antibody
SKU:
CAB5729
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 422-651 of human PIAS1 (NP_057250.1).
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8554
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of GFP-RNF168 transgenic U2OS cells using PIAS1 antibody (CAB5729). Green: GFP-RNF168 fusion protein expression for DNA damage marker. Blue: DAPI for nuclear staining. RNF168 (GFP) can be used to mark cells damaged by UV-A laser for they always gather around DNA damage region.
