The PI3 Kinase p85 Alpha Rabbit Monoclonal Antibody (CAB4992) is a valuable tool for researchers studying the PI3 Kinase pathway, which is essential for cell growth, proliferation, and survival. This antibody, produced in rabbits, is highly specific to the p85 alpha subunit of PI3 Kinase and is validated for use in Western blot and immunohistochemistry applications.PI3 Kinase p85 alpha is a regulatory subunit of PI3 Kinase, playing a key role in transducing signals from cell surface receptors to downstream signaling pathways involved in cell metabolism, growth, and survival.
Dysregulation of the PI3 Kinase pathway is often observed in cancer and other diseases, making this antibody an important tool for investigating the role of PI3 Kinase p85 alpha in disease progression.By enabling researchers to detect and analyze PI3 Kinase p85 alpha in various cell types and tissues, this antibody is essential for studies in cancer biology, cell signaling, and drug development. Its high specificity and sensitivity make it a reliable tool for understanding the complex mechanisms underlying the PI3 Kinase pathway and its implications for disease.
Product Name:
PI3 Kinase p85 alpha Rabbit Monoclonal Antibody
SKU:
CAB4992
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PI3 Kinase p85 alpha (P27986).
cell-cell junction, cis-Golgi network, cytoplasm, cytosol, nucleus, perinuclear region of cytoplasm, plasma membrane
Calculated MW:
84kDa
Observed MW:
85kDa
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
5295
Clone Number:
ARC55272
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PI3 Kinase p85 alpha Rabbit mAb (CAB4992) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
