PHYKPL Antibody (PACO15356)
- SKU:
- PACO15356
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PHYKPL Antibody (PACO15356)
The PHYKPL Polyclonal Antibody (PAC015356) is a valuable tool for studying PHYKPL, an enzyme involved in the biosynthesis of coenzyme Q 10. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PHYKPL protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential instrument for researchers in the fields of biochemistry and metabolic disorders.
PHYKPL plays a crucial role in the synthesis of coenzyme Q 10, a vital component in the electron transport chain and mitochondrial function. Dysregulation of PHYKPL activity has been linked to various metabolic disorders and diseases, making it a promising target for therapeutic interventions. Understanding the function and regulation of PHYKPL is key to developing treatments for conditions related to coenzyme Q 10 deficiency and mitochondrial dysfunction.
| Antibody Name: | PHYKPL Antibody (PACO15356) |
| Antibody SKU: | PACO15356 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human AGXT2L2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human lymphoma tissue, Primary antibody: PACO15356(AGXT2L2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. |
| Background: | This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphohydroxylysinuria. Alternative splicing results in multiple transcript variants. |
| Synonyms: | 5-phosphohydroxy-L-lysine phospho-lyase |
| UniProt Protein Function: | AGXT2L2: Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 4.2.3.134; TransferaseChromosomal Location of Human Ortholog: 5q35.3Cellular Component: mitochondrial matrixMolecular Function: identical protein binding; lyase activity; protein binding; pyridoxal phosphate binding; transaminase activityBiological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; lysine catabolic processDisease: Phosphohydroxylysinuria |
| UniProt Protein Details: | |
| NCBI Summary: | This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphohydroxylysinuria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
| UniProt Code: | Q8IUZ5 |
| NCBI GenInfo Identifier: | 74750645 |
| NCBI Gene ID: | 85007 |
| NCBI Accession: | Q8IUZ5.1 |
| UniProt Secondary Accession: | Q8IUZ5,Q8WYS6, Q96HW8, A8K7P6, B3KN36, D3DWP9 |
| UniProt Related Accession: | Q8IUZ5 |
| Molecular Weight: | 18,857 Da |
| NCBI Full Name: | 5-phosphohydroxy-L-lysine phospho-lyase |
| NCBI Synonym Full Names: | 5-phosphohydroxy-L-lysine phospho-lyase |
| NCBI Official Symbol: | PHYKPLÂ Â |
| NCBI Official Synonym Symbols: | PHLU; AGXT2L2Â Â |
| NCBI Protein Information: | 5-phosphohydroxy-L-lysine phospho-lyase |
| UniProt Protein Name: | 5-phosphohydroxy-L-lysine phospho-lyase |
| UniProt Synonym Protein Names: | Alanine--glyoxylate aminotransferase 2-like 2 |
| Protein Family: | |
| UniProt Gene Name: | PHYKPLÂ Â |
| UniProt Entry Name: | AT2L2_HUMAN |
Related Products
PHYKPL Antibody (PACO05554)
€269
PHYKPL Antibody (PACO15355)
€339
PHYKPL Antibody (PACO07651)
€459
SPEF2 Antibody (PACO64977)
€339
C1QTNF9 Antibody (PACO64617)
€339
POTEE Antibody (PACO64901)
€339
GPRIN2 Antibody (PACO64745)
€319
LCMT1 Antibody (PACO64821)
€319
ompF Antibody (PACO64865)
€339