PHOX2B Rabbit Monoclonal Antibody (CAB6816)
- SKU:
- CAB6816
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | PHOX2B Rabbit Monoclonal Antibody |
SKU: | CAB6816 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 215-314 of human PHOX2B (NP_003915.2). |
Sequence: | GGGP SPAG APGA AGPG GPGG EPGK GGAA AAAA AAAA AAAA AAAA AAGG LAAA GGPG QGWA PGPG PITS IPDS LGGP FASV LSSL QRPN GAKA ALVK SSMF |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CCHS; PMX2B; NBLST2; NBPhox; PHOX2B |
Positive Sample: | SH-SY5Y,Neuro-2a |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus |
Calculated MW: | 32kDa |
Observed MW: | 35kDa |
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.
Purification Method: | Affinity purification |
Gene ID: | 8929 |
Clone Number: | ARC1420 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |