The Phox2B Rabbit Monoclonal Antibody (CAB6816) is a highly specific antibody designed for research involving the Phox2B protein, a transcription factor essential for the development of the autonomic nervous system. This antibody, raised in rabbits, is validated for use in various applications such as immunohistochemistry and Western blotting, enabling detection and analysis of Phox2B in different cell types and tissues.Phox2B is known for its crucial role in controlling the development of neurons involved in the autonomic nervous system, making it a key player in regulating basic physiological functions such as breathing, heart rate, and digestion.
Dysregulation of Phox2B has been linked to disorders affecting these systems, making it a target of interest in research on conditions like congenital central hypoventilation syndrome (CCHS) and neuroblastoma.By using the Phox2B Rabbit Monoclonal Antibody (CAB6816), researchers can gain valuable insights into the functions and mechanisms of Phox2B, ultimately leading to a better understanding of its role in health and disease. Its high specificity and sensitivity make it a valuable tool for studies in neuroscience, developmental biology, and cancer research related to the autonomic nervous system.
Product Name:
PHOX2B Rabbit Monoclonal Antibody
SKU:
CAB6816
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 215-314 of human PHOX2B (NP_003915.2).
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.
Purification Method:
Affinity purification
Gene ID:
8929
Clone Number:
ARC1420
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PHOX2B Rabbit mAb (CAB6816) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
