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PHOX2B Polyclonal Antibody (CAB21990)

SKU:
CAB21990
$155
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Description

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Product Name:PHOX2B Polyclonal Antibody
SKU:CAB21990
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 260-314 of human PHOX2B (NP_003915.2).
Sequence:AGGL AAAG GPGQ GWAP GPGP ITSI PDSL GGPF ASVL SSLQ RPNG AKAA LVKS SMF
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:CCHS; PMX2B; NBLST2; NBPhox; PHOX2B
Positive Sample:Neuro-2a,SH-SY5Y
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:32kDa
Observed MW:37kDa

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.

Purification Method:Affinity purification
Gene ID:8929
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Neuro-2a cells using [KD Validated]PHOX2B Rabbit pAb(CAB21990) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:10s.

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