Description
Product Name: | PHOX2B Polyclonal Antibody |
SKU: | CAB21990 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-314 of human PHOX2B (NP_003915.2). |
Sequence: | AGGL AAAG GPGQ GWAP GPGP ITSI PDSL GGPF ASVL SSLQ RPNG AKAA LVKS SMF |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CCHS; PMX2B; NBLST2; NBPhox; PHOX2B |
Positive Sample: | Neuro-2a,SH-SY5Y |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 32kDa |
Observed MW: | 37kDa |
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.
Purification Method: | Affinity purification |
Gene ID: | 8929 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |