The PHOX2A Monoclonal Antibody (PACO56924) is a valuable tool for researchers studying the PHOX2A protein, a transcription factor involved in the development and function of the autonomic nervous system. This antibody is specifically designed for use in various experimental applications, including Western blotting, immunofluorescence, and immunohistochemistry. Produced in mice, this monoclonal antibody is highly specific for PHOX2A and has been validated for use in human samples. Its binding to the PHOX2A protein allows for accurate detection and analysis in a wide range of cell and tissue types, making it an essential tool for studying neural development, neuroblastoma, and other diseases related to the autonomic nervous system.
The PHOX2A Monoclonal Antibody (PACO56924) is a reliable and versatile reagent that can significantly enhance research efforts in neuroscience, developmental biology, and cancer biology. Its high specificity and sensitivity make it an ideal choice for scientists seeking to uncover the role of PHOX2A in health and disease.
Antibody Name:
PHOX2A Antibody (PACO56924)
Antibody SKU:
PACO56924
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Paired mesoderm homeobox protein 2A protein (150-264AA)
IHC image of PACO56924 diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system.
Background:
May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
Synonyms:
Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A), PHOX2A, ARIX PMX2A
UniProt Protein Function:
PHOX2A: May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. Defects in PHOX2A are the cause of congenital fibrosis of extraocular muscles type 2 (CFEOM2). CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM2 may result from the aberrant development of the oculomotor (nIII), trochlear (nIV) and abducens (nVI) cranial nerve nuclei. Belongs to the paired homeobox family.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 11q13.2Cellular Component: nuclear chromatinMolecular Function: transcription factor activityBiological Process: sympathetic nervous system development; regulation of respiratory gaseous exchange; trochlear nerve formation; transcription, DNA-dependent; oculomotor nerve formation; somatic motor neuron differentiation; midbrain development; positive regulation of transcription from RNA polymerase II promoter; locus ceruleus developmentDisease: Fibrosis Of Extraocular Muscles, Congenital, 2
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008]
