The Phospho1 Antibody (PAC052538) is a valuable tool for researchers studying phosphorylation events in cellular signaling pathways. This polyclonal antibody, generated using specific immunogens, targets the Phospho1 protein and is highly reactive with human samples. Validated for use in Western blot applications, this antibody enables the detection and analysis of Phospho1 in various cell types.Phospho1, a key player in the regulation of bone mineralization, is known for its role in promoting the phosphorylation of mineralization inhibitors. Dysregulation of Phospho1 activity has been associated with various bone disorders, making it a potential therapeutic target for bone-related diseases.
By understanding the phosphorylation status of Phospho1, researchers can gain insights into the mechanisms underlying these conditions and explore potential treatment strategies.With its high specificity and sensitivity, the Phospho1 Antibody (PAC052538) is an essential tool for studies focusing on cellular signaling, bone metabolism, and related diseases. Its ability to accurately detect phosphorylated forms of Phospho1 makes it a valuable asset for researchers seeking to unravel the complexities of phosphorylation-mediated cellular processes.
Antibody Name:
PHOSPHO1 Antibody (PACO52538)
Antibody SKU:
PACO52538
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Phosphoethanolamine/phosphocholine phosphatase protein (1-267AA)
Immunohistochemistry of paraffin-embedded human heart tissue using PACO52538 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO52538 at dilution of 1:100.
Background:
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
PHOSPHO1: Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.3.75; Lipid Metabolism - glycerophospholipid; PhosphataseChromosomal Location of Human Ortholog: 17q21.32Cellular Component: cytosolMolecular Function: phosphoric monoester hydrolase activity; pyrophosphatase activityBiological Process: phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process
