Zyxin Rabbit Polyclonal Antibody (CAB2135)
- SKU:
- CAB2135
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | Zyxin Rabbit Polyclonal Antibody |
SKU: | CAB2135 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-572 of human Zyxinin (NP_003452.1). |
Sequence: | PLTL KEVE ELEQ LTQQ LMQD MEHP QRQN VAVN ELCG RCHQ PLAR AQPA VRAL GQLF HIAC FTCH QCAQ QLQG QQFY SLEG APYC EGCY TDTL EKCN TCGE PITD RMLR ATGK AYHP HCFT CVVC ARPL EGTS FIVD QANR PHCV PDYH KQYA PRCS VCSE PIMP EPGR DETV RVVA LDKN FHMK CYKC EDCG KPLS IEAD DNGC FPLD GHVL CRKC HTAR AQT |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | ESP-2; HED-2; Zyxin |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cytoplasm, Nucleus, cytoskeleton, focal adhesion. |
Calculated MW: | 61kDa |
Observed MW: | 78kDa |
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
Purification Method: | Affinity purification |
Gene ID: | 7791 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |