The Zyxin Polyclonal Antibody (CAB2135) is a valuable tool for researchers studying the protein Zyxin, which is involved in cell adhesion and signal transduction. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding specifically to the Zyxin protein, this antibody allows for the detection and analysis of Zyxin in various cell types, making it an essential tool for studies in cell biology and cancer research.Zyxin is a key player in the regulation of cell adhesion and migration, making it a crucial target for research in cancer metastasis and tissue remodeling.
By understanding the function of Zyxin, researchers can gain valuable insights into the mechanisms underlying cell movement and invasion, which are crucial processes in cancer progression. The Zyxin Polyclonal Antibody (CAB2135) provides researchers with a reliable tool for studying the role of Zyxin in cell biology and cancer, paving the way for new therapeutic approaches in cancer treatment.
Product Name:
Zyxin Rabbit Polyclonal Antibody
SKU:
CAB2135
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 350-572 of human Zyxinin (NP_003452.1).
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
Purification Method:
Affinity purification
Gene ID:
7791
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using Zyxin Rabbit pAb (CAB2135).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
