Phospho-ZAP70-Y319 Rabbit Polyclonal Antibody (CABP0467)
- SKU:
- CABP0467
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- IF
- IP
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | Phospho-ZAP70-Y319 Rabbit Polyclonal Antibody |
SKU: | CABP0467 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic phosphorylated peptide around Y319 of human ZAP70 (NP_001070.2). |
Sequence: | SPYS D |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70; Phospho-ZAP70-Y319 |
Positive Sample: | Jurkat,Preincubated with blocking peptide |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Peripheral membrane protein. |
Calculated MW: | 70kDa |
Observed MW: | 70kDa |
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 7535 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |