The Phospho-YWHAZ/YWHAB (S184/186) Antibody (PAC005318) is a valuable tool for researchers studying phosphorylation events in the YWHAZ and YWHAB proteins. These proteins belong to the 14-3-3 family of regulatory molecules and are involved in diverse cellular processes such as signal transduction, cell cycle regulation, and apoptosis.This antibody, generated in rabbits, is highly specific for phosphorylated serine residues at positions 184 and 186 on YWHAZ and YWHAB. It has been validated for use in Western blot and immunohistochemistry applications, allowing for the detection and analysis of phosphorylated YWHAZ and YWHAB in various cell types and tissue samples.Phosphorylation of YWHAZ and YWHAB plays a crucial role in modulating their functions and interactions with other signaling molecules.
Dysregulation of these proteins has been implicated in a variety of diseases, including cancer, neurodegenerative disorders, and metabolic diseases. Therefore, studying the phosphorylation status of YWHAZ and YWHAB can provide valuable insights into disease mechanisms and potential therapeutic targets.Overall, the Phospho-YWHAZ/YWHAB (S184/186) Antibody is an essential tool for researchers interested in unraveling the complex regulatory networks involving YWHAZ and YWHAB phosphorylation and its implications in human health and disease.
Synthesized peptide derived from human 14-3-3 β / zeta around the phosphorylation site of S184/186.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
YWHAZ; 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; KCIP-1; YWHAB; 14-3-3 protein β/α; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
UniProt Protein Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
NCBI Summary:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
