The YBX1 Polyclonal Antibody (CAB15696) is a valuable tool for researchers studying the Y-box binding protein 1 (YBX1), a multifunctional protein involved in RNA transcription, splicing, and translation. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting YBX1 in human samples, making it ideal for use in Western blot and immunohistochemistry applications.YBX1 plays a crucial role in various cellular processes, including DNA repair, cell proliferation, and apoptosis, making it a key player in cancer progression and resistance to therapy.
By targeting YBX1 with this polyclonal antibody, researchers can gain valuable insights into the mechanisms driving cancer development and identify potential therapeutic targets.With its high reactivity and reliability in detecting YBX1 protein, the YBX1 Polyclonal Antibody (CAB15696) is an essential tool for scientists exploring the role of YBX1 in cancer biology, drug resistance, and other cellular processes. Its versatility and specificity make it an invaluable asset for any laboratory conducting research in the fields of oncology, cell biology, and molecular biology.
Product Name:
YB-1/YBX1 Rabbit Polyclonal Antibody
SKU:
CAB15696
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human YB-1/YB-1/YBX1 (NP_004550.2).
This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes.
Purification Method:
Affinity purification
Gene ID:
4904
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of HepG2 cells, using YB-1/YB-1/YBX1 antibody (CAB15696) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
