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WASP Rabbit Polyclonal Antibody (CAB0978)

SKU:
CAB0978
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 1 Anti-WAS Antibody CAB0978
  • Cell Biology Antibodies 1 Anti-WAS Antibody CAB0978
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:WASP Rabbit Polyclonal Antibody
SKU:CAB0978
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human WASPP (NP_000368.1).
Sequence:GAEH WTKE HCGA VCFV KDNP QKSY FIRL YGLQ AGRL LWEQ ELYS QLVY STPT PFFH TFAG DDCQ AGLN FADE DEAQ AFRA LVQE KIQK RNQR QSGD RRQL PPPP TPAN EERR GGLP PLPL HPGG DQGG PPVG PLSL GLAT VDIQ NPDI TSSR YRGL PAPG PSPA DKKR SGKK KISK ADIG APSG FKHV SHV
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:THC; IMD2; SCNX; THC1; WASP; WASPA
Positive Sample:HL-60,THP-1,Ramos
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, cytoskeleton.
Calculated MW:53kDa
Observed MW:62kDa

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Purification Method:Affinity purification
Gene ID:7454
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using WASPP Antibody (CAB0978) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).

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