VAV1 Rabbit Polyclonal Antibody (CAB15108)
- SKU:
- CAB15108
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | VAV1 Rabbit Polyclonal Antibody |
SKU: | CAB15108 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 374-590 of human VAV1 (NP_005419.2). |
Sequence: | KRDN ETLR QITN FQLS IENL DQSL AHYG RPKI DGEL KITS VERR SKMD RYAF LLDK ALLI CKRR GDSY DLKD FVNL HSFQ VRDD SSGD RDNK KWSH MFLL IEDQ GAQG YELF FKTR ELKK KWME QFEM AISN IYPE NATA NGHD FQMF SFEE TTSC KACQ MLLR GTFY QGYR CHRC RASA HKEC LGRV PPCG RHGQ DFPG TMKK DKLH RRAQ DKKR N |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | VAV; VAV1 |
Positive Sample: | Jurkat,Raji,Mouse thymus,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | cell-cell junction, cytoplasm, cytosol, plasma membrane |
Calculated MW: | 98kDa |
Observed MW: | 95kDa |
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method: | Affinity purification |
Gene ID: | 7409 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |