The Phospho-TYK2 (Y1054/1055) Polyclonal Antibody (CABP0543) is a crucial tool for researchers studying TYK2, a key signaling protein involved in the immune response. This antibody, generated in rabbits, has high specificity for human TYK2 samples and has been validated for use in Western blot applications. It selectively binds to the phosphorylated form of TYK2 at Y1054/1055, enabling precise detection and analysis in various cell types.TYK2 is a member of the Janus kinase (JAK) family and plays a vital role in cytokine signaling pathways, particularly in regulating immune responses and inflammation.
Phosphorylation at Y1054/1055 is known to be crucial for TYK2 activation, making this antibody essential for understanding the molecular mechanisms underlying immune regulation.By using the Phospho-TYK2 (Y1054/1055) Polyclonal Antibody in their research, scientists can gain insight into the role of TYK2 in various diseases, including autoimmune disorders, inflammatory conditions, and potentially cancer. This antibody is a valuable tool for studying signaling pathways and developing targeted therapies that modulate immune responses effectively.
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35.
Purification Method:
Affinity purification
Gene ID:
7297
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using Phospho-Tyk2-Y1054/1055 Rabbit pAb (CABP0543) at 1:1000 dilution.NIH/3T3 cells were treated by IFN-α (100 ng/ml) at 37℃ for 30 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
