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Phospho-TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA3E/TUBA4A (Y272) Antibody (PACO05344)

SKU:
PACO05344
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Phospho-TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA3E/TUBA4A (Y272) Antibody (PACO05344)

The Phospho-TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA3E/TUBA4A (Y272) Polyclonal Antibody (PACO05344) is a valuable tool for researchers studying tubulin proteins involved in cellular functions such as cell division, intracellular transport, and cell motility. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. It specifically binds to the phosphorylated form of tubulin proteins, allowing for detection and analysis in various cell types.Tubulins are essential components of the cytoskeleton and are critical for maintaining cell shape and structure. The phosphorylation of tubulins has been linked to various cellular processes, including signaling pathways, cell cycle progression, and cell migration.

By targeting the phosphorylated form of specific tubulin isoforms, this antibody enables researchers to investigate the role of tubulins in cellular function and disease pathogenesis.Research into tubulin phosphorylation is important for understanding fundamental cellular processes and identifying potential therapeutic targets for diseases such as cancer, neurodegenerative disorders, and developmental abnormalities. The Phospho-TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA3E/TUBA4A (Y272) Polyclonal Antibody is an essential tool for scientists studying tubulin phosphorylation and its implications in various

Antibody Name:Phospho-TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA3E/TUBA4A (Y272) Antibody (PACO05344)
Antibody SKU:PACO05344
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:40000, WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthesized peptide derived from human Tubulin α 1/3/4 around the phosphorylation site of Y272.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:TUBA1A; TUBA3; Tubulin α-1A chain; α-tubulin 3; Tubulin B-α-1; Tubulin α-3 chain; TUBA1B; Tubulin α-1B chain; α-tubulin ubiquitous; Tubulin K-α-1; Tubulin α-ubiquitous chain; TUBA1C; TUBA6; Tubulin α-1C c
UniProt Protein Function:TUBA1A: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Expressed at a high level in fetal brain. Belongs to the tubulin family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: microtubule; recycling endosome; cytoplasmic microtubule; cytosol; nucleus

Molecular Function:GTPase activity; protein domain specific binding; protein binding; GTP binding; structural constituent of cytoskeleton; structural molecule activity

Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; cell division; organelle organization and biogenesis; cytoskeleton-dependent intracellular transport; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule-based process

Disease: Lissencephaly 3

NCBI Summary:Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
UniProt Code:Q71U36
NCBI GenInfo Identifier:55977864
NCBI Gene ID:7846
NCBI Accession:Q71U36.1
UniProt Secondary Accession:Q71U36,P68363,
UniProt Related Accession:Q71U36
Molecular Weight:~ 55kDa
NCBI Full Name:Tubulin alpha-1A chain
NCBI Synonym Full Names:tubulin alpha 1a
NCBI Official Symbol:TUBA1A  
NCBI Official Synonym Symbols:LIS3; TUBA3; B-ALPHA-1  
NCBI Protein Information:tubulin alpha-1A chain
UniProt Protein Name:Tubulin alpha-1A chain
UniProt Synonym Protein Names:Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain
Protein Family:Tubulin
UniProt Gene Name:TUBA1A  
UniProt Entry Name:TBA1A_HUMAN

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