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Anti-Phospho-TSC2-S1387 Antibody (CABP1117)

SKU:
CABP1117
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
€419
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Description

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Anti-Phospho-TSC2-S1387 Antibody (CABP1117)

The Phospho-TSC2 (S1387) Polyclonal Antibody (CABP1117) is a valuable tool for researchers studying the TSC2 protein, a key regulator of cell growth and proliferation. This antibody, raised in rabbits, specifically detects phosphorylation at serine 1387 of the TSC2 protein and is highly reactive with human samples. Validated for use in Western blot applications, the antibody allows for precise detection and analysis of TSC2 phosphorylation in various cell types.TSC2, also known as tuberin, is a tumor suppressor protein that acts as a negative regulator of the mTOR signaling pathway. Phosphorylation of TSC2 at serine 1387 is a critical event that modulates its activity, influencing cell growth and metabolism.

Research into the phosphorylation status of TSC2 can provide insights into the dysregulation of mTOR signaling in diseases like cancer and tuberous sclerosis complex (TSC).By using the Phospho-TSC2 (S1387) Polyclonal Antibody, researchers can unravel the complex signaling networks involving TSC2 phosphorylation and its impact on cellular processes. This antibody is an essential tool for studies in cancer biology, cell signaling, and the development of targeted therapies aimed at modulating the mTOR pathway. Gain a deeper understanding of TSC2 function and its implications in disease pathology with the reliable detection capabilities of the CABP1117 antibody.

Antibody Name:Anti-Phospho-TSC2-S1387 Antibody
Antibody SKU:CABP1117
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S1387 of human Tuberin/TSC2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:C2C12
Immunogen:A phospho specific peptide corresponding to residues surrounding S1387 of human Tuberin/TSC2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7249
Uniprot:P49815
Cellular Location:Cytoplasm, Membrane, Peripheral membrane protein
Calculated MW:25kDa/187-200kDa
Observed MW:200kDa
Anti-Phospho-TSC2-S1387 Antibody (CABP1117)Western blot - Phospho-TSC2-S1387 Rabbit pAb (CABP1117)
Synonyms:TSC2, LAM, PPP1R160, TSC4, tuberin
Background:Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Protein Function:TSC2: a product of the tumor suppressor gene TSC2. Tuberin and Hamartin (TSC1) form a tumor suppressor heterodimer that inhibits the mTOR nutrient signaling input. TSC1/TSC2 targets the small G protein Rheb, a novel mediator of the nutrient signaling input to mTOR. Functions as a Rheb GTPase activating protein (GAP). Four alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; TSC1-TSC2 complex

Molecular Function:GTPase activator activity; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding

Biological Process: anoikis; cell cycle arrest; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling cascade; negative regulation of TOR signaling pathway; negative regulation of Wnt receptor signaling pathway; neural tube closure; positive chemotaxis; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling cascade; protein localization; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; vesicle-mediated transport

Disease: Focal Cortical Dysplasia Of Taylor; Lymphangioleiomyomatosis; Tuberous Sclerosis 2

NCBI Summary:Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:P49815
NCBI GenInfo Identifier:269849475
NCBI Gene ID:7249
NCBI Accession:P49815.2
UniProt Secondary Accession:P49815,O75275, Q4LE71, Q8TAZ1, A7E2E2, B4DIL8, B4DIQ7 B4DRN2, B7Z2B8, C9J378,
UniProt Related Accession:P49815
Molecular Weight:25,773 Da
NCBI Full Name:Tuberin
NCBI Synonym Full Names:tuberous sclerosis 2
NCBI Official Symbol:TSC2  
NCBI Official Synonym Symbols:LAM; TSC4; PPP1R160  
NCBI Protein Information:tuberin
UniProt Protein Name:Tuberin
UniProt Synonym Protein Names:Tuberous sclerosis 2 protein
Protein Family:Tuberin
UniProt Gene Name:TSC2  

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