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Phospho-p53-T18 Rabbit Polyclonal Antibody (CABP0464)

SKU:
CABP0464
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
$503
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Description

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Product Name:Phospho-p53-T18 Rabbit Polyclonal Antibody
SKU:CABP0464
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic phosphorylated peptide around T18 of human p53 (NP_000537.3).
Sequence:QETF S
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:P53; BCC7; LFS1; BMFS5; TRP53; Phospho-p53-T18
Positive Sample:MDA
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Endoplasmic reticulum, Mitochondrion matrix, Nucleus, PML body.
Calculated MW:44kDa
Observed MW:54kDa

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Purification Method:Affinity purification
Gene ID:7157
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from MDA cells, using Phospho-p53-T18 Rabbit pAb (CABP0464).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.

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