The Phospho-TP53 (T18) Polyclonal Antibody (CABP0464) is a vital tool for researchers studying TP53, a tumor suppressor protein involved in cell cycle regulation and apoptosis. The antibody, produced in rabbits, exhibits high specificity towards phosphorylated TP53 at threonine 18 and is suitable for use in Western blot applications. Its ability to target this specific phosphorylation site allows for precise detection and analysis of TP53 protein levels in various biological samples, making it an essential tool for cancer research and drug development.Phosphorylation of TP53 at threonine 18 is known to impact its stability and activity, influencing cell survival and proliferation.
Dysregulation of TP53 phosphorylation has been linked to various types of cancer and other diseases, making it a key focus in molecular biology and therapeutic targeting. By studying the phosphorylation status of TP53, researchers can gain valuable insights into the mechanisms of tumorigenesis and identify potential strategies for treating TP53-related malignancies.Overall, the Phospho-TP53 (T18) Polyclonal Antibody (CABP0464) offers researchers a powerful tool for investigating the role of TP53 phosphorylation in cancer biology, providing valuable information for the development of targeted therapies and personalized treatment approaches.
Product Name:
Phospho-p53-T18 Rabbit Polyclonal Antibody
SKU:
CABP0464
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around T18 of human p53 (NP_000537.3).
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
Purification Method:
Affinity purification
Gene ID:
7157
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from MDA cells, using Phospho-p53-T18 Rabbit pAb (CABP0464).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
