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Phospho-TBK1/NAK-S172 Monoclonal Antibody (CABP1418)

SKU:
CABP1418
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$167 - $731
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Phospho-TBK1/NAK-S172 Monoclonal Antibody
SKU:CABP1418
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A phospho synthetic peptide corresponding to residues surrounding S172 of Human TBK1/NAK.
Tested Applications:WB ELISA
Recommended Dilution:WB,1:100 - 1:500
Synonyms:NAK; T2K; IIAE8; FTDALS4; Phospho-TBK1/NAK-S172
Positive Sample:NIH/3T3
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:84kDa
Observed MW:84kDa

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response.

Purification Method:Affinity purification
Gene ID:29110
Clone Number:ARC57906
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using Phospho-TBK1/NAK-S172 Rabbit mAb (CABP1418) at 1:500 dilution.NIH/3T3 cells were treated by Calyculin A (100 nM) at 37℃ for 30 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.

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