The Phospho-Tau Thr231 Rabbit Polyclonal Antibody (CABP0923) is a valuable tool for researchers studying tau protein phosphorylation, a key event in Alzheimer's disease and other neurodegenerative disorders. This antibody, generated in rabbits, specifically recognizes tau protein phosphorylated at threonine 231, allowing for precise detection and analysis in various cell types and tissues.Tau protein phosphorylation at threonine 231 is known to play a critical role in the regulation of tau function and aggregation, making this antibody particularly important for studies on neurodegeneration and neurobiology.
The antibody has been validated for use in Western blot applications and is highly reactive with human samples, providing reliable results for research in neuroscience and related fields.Understanding the mechanisms of tau protein phosphorylation at threonine 231 is essential for unraveling the pathogenesis of neurodegenerative diseases and developing targeted therapies. This antibody offers researchers a powerful tool for investigating the role of tau protein phosphorylation in disease progression and identifying potential therapeutic targets for treating neurodegenerative disorders.
Product Name:
Phospho-Tau-Thr231 Rabbit Polyclonal Antibody
SKU:
CABP0923
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic phosphorylated peptide around T548 of human Tau (NP_058519.3?).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using Phospho-Tau-T231 Rabbit pAb (CABP0923) at 1:1000 dilution.Mouse brain were treated by CIP (20ul CIP for each 400ul cell lysate) at 37℃ for 1 hour.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
