The Phospho-Tau (T231) Rabbit Monoclonal Antibody (CABP0053) is a valuable tool for researchers studying Tau protein phosphorylation, a key process implicated in Alzheimer's disease and other neurodegenerative disorders. This antibody, produced using rabbit monoclonal technology, is highly specific to the T231 phosphorylation site on the Tau protein, allowing for precise detection and analysis in various cell and tissue types.Tau protein plays a critical role in stabilizing microtubules in neurons, and abnormal phosphorylation of Tau has been linked to the formation of neurofibrillary tangles, a hallmark of Alzheimer's disease pathology.
By targeting the T231 phosphorylation site, researchers can gain insights into the mechanisms underlying Tau pathology and potentially identify new therapeutic targets for neurodegenerative diseases.This antibody has been validated for use in Western blot applications, providing researchers with a reliable tool for studying Tau phosphorylation dynamics in disease models and patient samples. Its high specificity and sensitivity make it an ideal choice for studies aiming to elucidate the role of Tau protein phosphorylation in neurodegeneration and explore potential therapeutic interventions targeting this pathway.
Product Name:
Phospho-Tau-T231 Rabbit Monoclonal Antibody
SKU:
CABP0053
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around t231 of human Tau (P10636).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Clone Number:
ARC0021
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Confocal imaging of paraffin-embedded Rat brain tissue using Phospho-Tau-T231 Rabbit mAb (AP0053, dilution 1:100) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). DAPI was used for nuclear staining (Blue). Objective: 40x. Perform microwave antigen retrieval with 0.01 M citrate buffer (pH 6.0) prior to IF staining.
