The Phospho-Tau T231 Polyclonal Antibody is a crucial tool for researchers studying Tau protein phosphorylation, a key factor in neurodegenerative diseases like Alzheimer's. This antibody, generated in rabbits, exhibits high specificity for human samples and is validated for use in Western blotting applications. By binding to the phosphorylated Tau protein at the T231 site, researchers can accurately detect and analyze Tau phosphorylation levels in various cell types, providing valuable insights into the pathology of neurodegenerative disorders.
The hyperphosphorylation of Tau protein is a hallmark of Alzheimer's disease and other tauopathies, leading to the formation of neurofibrillary tangles and neuronal dysfunction. Targeting specific phosphorylation sites, such as T231, is essential for understanding the pathogenic mechanisms underlying these disorders and developing potential therapeutic interventions. The Phospho-Tau T231 Polyclonal Antibody enables researchers to investigate Tau phosphorylation dynamics and explore novel treatment strategies for neurodegenerative diseases.
Product Name:
Phospho-Tau-T231 Polyclonal Antibody
SKU:
CABP0401
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T231 of human Tau.
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Phospho-Tau-T231 Rabbit pAb (CABP0401) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
