The Phospho-Tau (T205) Rabbit Polyclonal Antibody (CABP0168) is a highly specific antibody designed for research involving phosphorylated tau protein at threonine 205, a key post-translational modification associated with Alzheimer's disease and other neurodegenerative disorders. The antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Tau protein abnormalities, including hyperphosphorylation at specific sites such as T205, are hallmarks of Alzheimer's disease pathology, leading to the formation of neurofibrillary tangles and neuronal cell death. This antibody specifically targets phospho-tau at T205, enabling precise detection and analysis of tau protein phosphorylation levels in various cell types and tissue samples.
The Phospho-Tau (T205) Rabbit Polyclonal Antibody is an essential tool for researchers studying the pathogenesis of neurodegenerative diseases and investigating potential therapeutic strategies targeting tau protein dysfunction. With its high specificity and sensitivity, this antibody is ideal for use in studies exploring the role of phospho-tau in disease mechanisms and for identifying novel biomarkers for early diagnosis and treatment monitoring in neurodegenerative disorders.
Product Name:
Phospho-Tau-T205 Rabbit Polyclonal Antibody
SKU:
CABP0168
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T205 of human Tau (NP_001190181.1).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain, using Phospho-Tau-T205 Rabbit pAb (CABP0168) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
