The Phospho-Tau (T181) Monoclonal Antibody (CABP1324) is a valuable tool for researchers conducting studies on neurodegenerative diseases, particularly Alzheimer's disease. This antibody, produced in a monoclonal configuration, is highly specific and sensitive for detecting phosphorylated Tau protein at the T181 site. It is validated for use in various applications, including immunohistochemistry and Western blotting.Phosphorylated Tau protein at the T181 site is a hallmark feature of neurofibrillary tangles in Alzheimer's disease, making it a key target for research into disease mechanisms and potential therapeutic interventions.
By using this antibody, researchers can accurately detect and analyze levels of phosphorylated Tau protein in tissue samples, providing valuable insights into disease progression and potential treatment strategies.Overall, the Phospho-Tau (T181) Monoclonal Antibody (CABP1324) is an essential tool for researchers seeking to delve deeper into the role of phosphorylated Tau protein in neurodegenerative diseases, paving the way for advancements in diagnosis, treatment, and ultimately, a greater understanding of these complex disorders.
Product Name:
Phospho-Tau-T181 Monoclonal Antibody
SKU:
CABP1324
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T181 of human Phospho-Tau-T181 (NP_001190181.1).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Clone Number:
ARC54951
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells transfected with CDK5+CDK5R1+Tau and CDK5+CDK5R1+mutant Tau(T181/T217A) using Phospho-Tau-T181 Rabbit mAb (CABP1324) at1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
