The Phospho-Tau (Ser416) Rabbit Polyclonal Antibody (CABP1101) is a valuable tool for researchers studying phosphorylated tau protein in various cellular processes. This antibody, specifically designed for detecting phosphorylation at serine 416 on tau, is highly reactive with human samples and has been validated for use in Western blot applications.Tau protein is commonly associated with neurodegenerative disorders such as Alzheimer's disease, where abnormal phosphorylation leads to the formation of tau tangles in the brain. The Phospho-Tau (Ser416) antibody allows for the detection and analysis of phosphorylated tau in different cell types, providing insights into the role of tau phosphorylation in neurodegeneration.
With its ability to specifically target phosphorylated tau at serine 416, this antibody is a valuable tool for researchers investigating the pathological mechanisms underlying neurodegenerative diseases. By understanding the phosphorylation status of tau protein, researchers can further explore potential therapeutic targets for these devastating diseases.
Product Name:
Phospho-Tau-Ser416 Rabbit Polyclonal Antibody
SKU:
CABP1101
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around S416 of human Tau (NP_005901.2).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using Phospho-Tau-Ser416 Rabbit pAb (CAB0002).NIH/3T3 cells were treated by CIP(20uL/400ul) at 37℃ for 1 hour.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
