The Phospho-Tau (Ser404) Polyclonal Antibody (CABP1100) is a valuable tool for researchers studying Tau protein phosphorylation, a key event in Alzheimer's disease and other neurodegenerative disorders. Raised in rabbits, this antibody is highly specific for phosphorylated Tau at Ser404 and is validated for use in various applications, including Western blot and immunohistochemistry.Tau protein plays a crucial role in stabilizing microtubules in neurons, and abnormal phosphorylation of Tau disrupts this function, leading to the formation of neurofibrillary tangles characteristic of Alzheimer's disease.
By targeting the phosphorylated form of Tau at Ser404, researchers can investigate the mechanisms underlying Tau pathology and explore potential therapeutic strategies for neurodegenerative diseases.The Phospho-Tau (Ser404) Polyclonal Antibody is an essential tool for studying the role of Tau phosphorylation in neurodegeneration and for identifying potential targets for drug development in the field of neuroscience. Its high specificity and sensitivity make it a valuable asset for researchers aiming to unravel the complexities of Tau biology and its implications for disease progression.
Product Name:
Phospho-Tau-Ser404 Rabbit Polyclonal Antibody
SKU:
CABP1100
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around S404 of human Tau (NP_005901.2).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of paraffin-embedded Rat brain using Phospho-Tau-Ser404 Rabbit pAb (CABP1100) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
