The Phospho-Tau S404 Monoclonal Antibody is a valuable tool for research involving the phosphorylation of Tau protein at the S404 site. Tau protein plays a crucial role in the pathogenesis of Alzheimer's disease and other tauopathies, making it a key target for study in neurodegenerative research. This monoclonal antibody, produced through hybridoma technology, is highly specific and sensitive for detecting phosphorylated Tau at the S404 site. It is validated for use in immunohistochemistry, immunofluorescence, and other cellular assays, allowing for the visualization and quantification of phosphorylated Tau in various experimental settings.
The phosphorylation of Tau at the S404 site has been implicated in the formation of neurofibrillary tangles, a hallmark pathology of Alzheimer's disease. By using this antibody, researchers can gain insights into the molecular mechanisms underlying tau pathology and potentially identify novel therapeutic targets for the treatment of neurodegenerative disorders.Overall, the Phospho-Tau S404 Monoclonal Antibody is a valuable tool for researchers studying tau phosphorylation and its role in neurodegeneration, offering high specificity and sensitivity for the detection of phosphorylated Tau at the S404 site.
Product Name:
Phospho-Tau-S404 Monoclonal Antibody
SKU:
CABP1378
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around S404 of human Tau.
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Clone Number:
ARC58154
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from rat brain, using Phospho-Tau-S404 Rabbit mAb (CABP1378) at 1:5000 dilution.Rat brain cells were treated by λ-PP mixed solution (1ul) at 30℃ for 30 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
