The Phospho-Tau S396 Rabbit Monoclonal Antibody (CABP1028) is an essential tool for researchers studying tau protein phosphorylation, a key process involved in Alzheimer's disease and other neurodegenerative disorders. This antibody, generated in rabbits, is highly specific to phosphorylated tau at the S396 site in human samples and has been validated for use in Western blot and immunohistochemistry applications.Tau protein is crucial for maintaining the structure and function of neurons, but abnormal phosphorylation of tau can lead to the formation of neurofibrillary tangles, a hallmark of Alzheimer's disease.
The phosphorylation of tau at the S396 site has been linked to the progression of tau pathology, making it a critical target for drug development and biomarker discovery in neurodegenerative diseases.By using the Phospho-Tau S396 Rabbit Monoclonal Antibody (CABP1028), researchers can accurately detect and quantify phospho-tau S396 levels in various cell types and tissue samples, providing valuable insights into the mechanisms underlying tau pathology. This antibody is a valuable tool for advancing our understanding of neurodegenerative diseases and developing targeted therapies to combat them.
Product Name:
Phospho-Tau-S396 Rabbit Monoclonal Antibody
SKU:
CABP1028
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around S396 of human tau (NP_005901.2)
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Clone Number:
ARC1573
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using Phospho-Tau-S396 Rabbit mAb (CABP1028) at 1:1000 dilution.Mouse brain were treated by CIP(20μL/400μL) at 37℃ for 1 hour.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
