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Phospho-SYT1/SYT2 (S309/306) Antibody (PACO00294)

SKU:
PACO00294
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Phospho-SYT1/SYT2 (S309/306) Antibody (PACO00294)

The Phospho-Syt1/Syt2 (S309/306) Antibody (PACO00294) is a valuable tool for researchers studying synaptic transmission and calcium signaling pathways. This antibody specifically recognizes phosphorylated forms of Synaptotagmin 1 and Synaptotagmin 2 at Serine 309 and 306, respectively. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications.Synaptotagmins are crucial proteins involved in calcium-dependent neurotransmitter release at synapses. Phosphorylation at specific sites like S309 and S306 can modulate the function of Synaptotagmins, impacting synaptic vesicle fusion and neurotransmitter release.

Understanding the regulation of these proteins is essential for unraveling the complexities of synaptic transmission and neuronal communication.This antibody's ability to specifically detect phosphorylated forms of Synaptotagmin 1 and Synaptotagmin 2 makes it a valuable tool for researchers investigating synaptic plasticity, neuronal communication, and neurological disorders. By enabling accurate detection and analysis of phosphorylated Synaptotagmins, this antibody contributes to advancing our understanding of the molecular mechanisms underlying brain function and dysfunction.

Antibody Name:Phospho-SYT1/SYT2 (S309/306) Antibody
Antibody SKU:PACO00294
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human Synaptotagmin 1/2 around the phosphorylation site of S309/306.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:SYT1; SVP65; SYT; Synaptotagmin-1; Synaptotagmin I; SytI; p65; SYT2; Synaptotagmin-2; Synaptotagmin II; SytII
UniProt Protein Function:SYT1: an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
UniProt Protein Details:

Protein type:Membrane protein, integral; Vesicle; Calcium-binding

Chromosomal Location of Human Ortholog: 12cen-q21

Cellular Component: neuron projection; plasma membrane; synaptic vesicle; synaptic vesicle membrane

Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; low-density lipoprotein receptor binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; SNARE binding; syntaxin-1 binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; detection of calcium ion; glutamate secretion; neurotransmitter secretion; positive regulation of synaptic transmission; protein homooligomerization; regulation of calcium ion-dependent exocytosis; regulation of exocytosis; regulation of synaptic transmission, glutamatergic; synaptic transmission; synaptic vesicle endocytosis; vesicle fusion

NCBI Summary:The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
UniProt Code:P21579
NCBI GenInfo Identifier:135086
NCBI Gene ID:6857
NCBI Accession:P21579.1
UniProt Secondary Accession:P21579,Q6AI31,
UniProt Related Accession:P21579
Molecular Weight:47,573 Da
NCBI Full Name:Synaptotagmin-1
NCBI Synonym Full Names:synaptotagmin 1
NCBI Official Symbol:SYT1  
NCBI Official Synonym Symbols:P65; SYT; SVP65  
NCBI Protein Information:synaptotagmin-1
UniProt Protein Name:Synaptotagmin-1
UniProt Synonym Protein Names:Synaptotagmin I; SytI; p65
Protein Family:Synaptotagmin
UniProt Gene Name:SYT1  
UniProt Entry Name:SYT1_HUMAN

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