The Phospho-STK11 (T189) Polyclonal Antibody (CABP0603) is a valuable tool for researchers studying the STK11 protein, a key component in cell signaling pathways involved in cell growth and proliferation. This antibody, produced in rabbits, is highly specific to the phosphorylated form of STK11 at threonine 189 and is validated for use in various applications, including Western blotting.STK11, also known as LKB1, is a tumor suppressor protein that is frequently mutated in various cancers, most notably in lung and cervical cancers. Phosphorylation of STK11 at threonine 189 has been linked to the regulation of its activity, affecting downstream signaling cascades involved in cell cycle regulation and apoptosis.
This antibody provides researchers with a reliable tool to study the phosphorylation status of STK11 in different cell types and under various conditions, helping to further our understanding of the role of STK11 in cancer development and progression. Ultimately, this antibody may aid in the identification of potential therapeutic targets for cancer treatment strategies aimed at manipulating STK11 signaling pathways.
Product Name:
Phospho-STK11-T189 Rabbit Polyclonal Antibody
SKU:
CABP0603
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T189 of human STK11 (NP_000446.1).
Sequence:
GGTL K
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
PJS; LKB1; hLKB1; Phospho-STK11-T189
Positive Sample:
A-431
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Membrane, Mitochondrion, Nucleus.
Calculated MW:
49kDa
Observed MW:
54kDa
The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.
Purification Method:
Affinity purification
Gene ID:
6794
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
