The Phospho-STING (TMEM173 S366) Monoclonal Antibody is a cutting-edge tool for researchers studying the STING protein, a key player in the innate immune response to viral and bacterial infections. This antibody, derived from mouse hybridoma cells, is highly specific for detecting phosphorylation at serine 366 of the STING protein and is validated for use in immunofluorescence and immunoprecipitation assays.STING (Stimulator of Interferon Genes) is a crucial signaling molecule that activates the production of interferons and other cytokines in response to cytosolic DNA. Phosphorylation at serine 366 is known to be important for regulating STING activity and downstream signaling pathways.
By using this Phospho-STING antibody, researchers can gain valuable insights into the mechanisms of immune activation and response to pathogens.This antibody is a valuable tool for studies in virology, immunology, and infectious diseases, as well as for investigating the role of STING in cancer immunotherapy. With its high specificity and sensitivity, the Phospho-STING (TMEM173 S366) Monoclonal Antibody is an essential addition to any lab conducting research on innate immunity and immune regulation.
Product Name:
Phospho-STING/TMEM173-S366 Monoclonal Antibody
SKU:
CABP1369
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around S366 of human STING1 (NP_938023.1).
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
340061
Clone Number:
ARC57910
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of THP-1, using Phospho-STING/TMEM173-S366 antibody (CABP1369) at 1:1000 dilution.THP-1 cells were transfection with poly(dA:dT) (5μg/mL) for 3 hours.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
