The Phospho-Stathmin (S38) Polyclonal Antibody (CABP0221) is a valuable tool for researchers studying the phosphorylation of the Stathmin protein at Serine 38. Stathmin is a key regulator of microtubule dynamics and plays a critical role in cell proliferation, migration, and cell cycle progression.This antibody, raised in rabbits, is highly specific and has been validated for use in Western blot applications. It recognizes the phosphorylated form of Stathmin at Serine 38, allowing for the detection and quantification of this post-translational modification in cell lysates and tissue samples.Phosphorylation of Stathmin at Serine 38 has been implicated in a variety of cellular processes, including mitotic spindle formation, cytoskeletal organization, and cell motility.
Dysregulation of Stathmin phosphorylation has been linked to cancer progression and metastasis, making it a potential target for therapeutic intervention.Overall, the Phospho-Stathmin (S38) Polyclonal Antibody (CABP0221) is a valuable tool for researchers interested in understanding the role of Stathmin phosphorylation in cellular signaling pathways, with potential implications for cancer biology and other disease states.
Product Name:
Phospho-Stathmin 1-S38 Rabbit Polyclonal Antibody
SKU:
CABP0221
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around S38 of human Stathmin 1 (NP_001138926.1).
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3925
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using Phospho-Stathmin 1-S38 Rabbit pAb (CABP0221) at 1:1000 dilution.NIH/3T3 cells were treated by Nocodazole (50 ng/ml) at 37℃ for 20 hours.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
