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Anti-Phospho-STAT6-Y641 Antibody (CABP0456)

SKU:
CABP0456
Product Type:
Antibody
Applications:
WB
IHC
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
€419
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Description

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Antibody Name:Anti-Phospho-STAT6-Y641 Antibody
Antibody SKU:CABP0456
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding Y641 of human STAT6
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa
Immunogen:A phospho specific peptide corresponding to residues surrounding Y641 of human STAT6
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6778
Uniprot:P42226
Cellular Location:Cytoplasm, Nucleus
Calculated MW:74kDa/81kDa/94kDa
Observed MW:110kDa
Anti-Phospho-STAT6-Y641 Antibody (CABP0456)Western blot analysis of extracts from HeLa cells, using Phospho-STAT6-Y641 antibody (CABP0456). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA.
Synonyms:D12S1644, IL-4-STAT, STAT6B, STAT6C, STAT6
Background:The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: cytoplasm; cytosol; lipid raft; nuclear chromatin; nucleoplasm

Molecular Function:identical protein binding; protein binding; protein phosphatase binding; signal transducer activity; transcription factor activity

Biological Process: mammary gland epithelial cell proliferation; negative regulation of T-helper 2 type immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of interferon type I production; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; signal transduction; T-helper 1 cell lineage commitment; transcription, DNA-dependent

NCBI Summary:The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Code:P42226
NCBI GenInfo Identifier:1174459
NCBI Gene ID:6778
NCBI Accession:P42226.1
UniProt Secondary Accession:P42226,Q5FBW5, Q71UP4, A8K316, B7ZA27, F5GXI9,
UniProt Related Accession:P42226
Molecular Weight:
NCBI Full Name:Signal transducer and activator of transcription 6
NCBI Synonym Full Names:signal transducer and activator of transcription 6
NCBI Official Symbol:STAT6  
NCBI Official Synonym Symbols:STAT6B; STAT6C; D12S1644; IL-4-STAT  
NCBI Protein Information:signal transducer and activator of transcription 6
UniProt Protein Name:Signal transducer and activator of transcription 6
UniProt Synonym Protein Names:IL-4 Stat
Protein Family:Signal transducer and transcription activator
UniProt Gene Name:STAT6  
UniProt Entry Name:STAT6_HUMAN

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