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Anti-Phospho-SMC1-S957 Antibody (CABP1145)

SKU:
CABP1145
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Cycle
€419
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Description

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Anti-Phospho-SMC1-S957 Antibody (CABP1145)

The Phospho-SMC1 (S957) Rabbit Monoclonal Antibody (CABP1145) is designed for research involving the phosphorylation of Structural Maintenance of Chromosomes 1 (SMC1) at serine 957. SMC1 is a key component of the cohesin complex involved in regulating chromosome segregation and DNA repair. The antibody, raised in rabbits, is highly specific and sensitive for detecting phosphorylated SMC1 (S957) in human samples, making it ideal for use in Western blot applications.Phosphorylation of SMC1 at serine 957 plays a crucial role in the regulation of DNA damage response and cell cycle control. Dysregulation of this phosphorylation event has been linked to various diseases, including cancer and genetic disorders.

By targeting this specific phosphorylation site, researchers can gain insights into the mechanisms underlying these pathological conditions and potentially identify new therapeutic targets for intervention.The Phospho-SMC1 (S957) Rabbit Monoclonal Antibody (CABP1145) offers researchers a valuable tool for investigating the role of SMC1 phosphorylation in cellular processes and disease development. Its high specificity and sensitivity ensure reliable and accurate detection of phosphorylated SMC1 (S957) in various experimental settings, making it a valuable asset for studies in the fields of molecular biology, oncology, and genetic disorders.

Antibody Name:Anti-Phospho-SMC1-S957 Antibody
Antibody SKU:CABP1145
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S957 of human SMC1
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, NIH/3T3
Immunogen:A phospho specific peptide corresponding to residues surrounding S957 of human SMC1
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8243
Uniprot:Q14683
Cellular Location:Chromosome, Nucleus, centromere, kinetochore
Calculated MW:160kDa
Observed MW:160KDa
Anti-Phospho-SMC1-S957 Antibody (CABP1145)Western blot - Phospho-SMC1-S957 Rabbit mAb (CABP1145)
Synonyms:CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Background:Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
UniProt Protein Function:Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
NCBI Summary:Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
UniProt Code:Q14683
NCBI GenInfo Identifier:29336622
NCBI Gene ID:8243
NCBI Accession:Q14683.2
UniProt Secondary Accession:Q14683,O14995, Q16351, Q2M228,
UniProt Related Accession:Q14683
Molecular Weight:155 kDa
NCBI Full Name:Structural maintenance of chromosomes protein 1A
NCBI Synonym Full Names:structural maintenance of chromosomes 1A
NCBI Official Symbol:SMC1A  
NCBI Official Synonym Symbols:SMC1; SMCB; CDLS2; SB1.8; SMC1L1; DXS423E; SMC1alpha  
NCBI Protein Information:structural maintenance of chromosomes protein 1A
UniProt Protein Name:Structural maintenance of chromosomes protein 1A
UniProt Synonym Protein Names:Sb1.8
Protein Family:Structural maintenance of chromosomes protein
UniProt Gene Name:SMC1A  

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