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Anti-Phospho-RSK1-S380 Antibody (CABP1147)

SKU:
CABP1147
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Cycle
€419
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Description

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Anti-Phospho-RSK1-S380 Antibody (CABP1147)

The Phospho-RSK1 (S380) Rabbit Monoclonal Antibody (CABP1147) is a valuable tool for research involving the RSK1 protein, specifically phosphorylated at serine 380. RSK1 is a kinase involved in cell proliferation, differentiation, and survival, making it a key player in cancer research and signaling pathways.This antibody, generated in rabbits, is highly specific and sensitive towards human samples, making it ideal for Western blot applications. It binds specifically to the phosphorylated form of RSK1 at serine 380, allowing for precise detection and analysis in various cell types.

RSK1 has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions. Understanding the phosphorylation status of RSK1 at serine 380 is crucial for unraveling its role in cellular processes and disease progression.Overall, the Phospho-RSK1 (S380) Rabbit Monoclonal Antibody (CABP1147) is a valuable tool for researchers studying cell signaling pathways, cancer biology, and kinase activity, providing crucial insights into the role of RSK1 in disease development and progression.

Antibody Name:Anti-Phospho-RSK1-S380 Antibody
Antibody SKU:CABP1147
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S380 of human RSK1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:C6
Immunogen:A phospho specific peptide corresponding to residues surrounding S380 of human RSK1
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6195
Uniprot:Q15418
Cellular Location:
Calculated MW:90kDa
Observed MW:90KDa
Anti-Phospho-RSK1-S380 Antibody (CABP1147)Western blot - Phospho-RSK1-S380 Rabbit mAb (CABP1147)
Synonyms:HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk
Background:This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Protein Function:p90RSK: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.
UniProt Protein Details:

Protein type:EC 2.7.11.1; Protein kinase, AGC; Kinase, protein; Translation; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; RSK subfamily

Chromosomal Location of Human Ortholog: 1p

Cellular Component: nucleoplasm; cytoplasm; spindle; cytosol; nucleus

Molecular Function:protein serine/threonine kinase activity; protein binding; caspase inhibitor activity; protein serine/threonine/tyrosine kinase activity; magnesium ion binding; ATP binding

Biological Process: regulation of transcription in response to stress; axon guidance; nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; regulation of translation in response to stress; toll-like receptor 3 signaling pathway; negative regulation of caspase activity; cell cycle; signal transduction; protein amino acid phosphorylation; positive regulation of cell growth; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; synaptic transmission; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; toll-like receptor 4 signaling pathway; negative regulation of apoptosis

NCBI Summary:This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q15418
NCBI GenInfo Identifier:20178306
NCBI Gene ID:6195
NCBI Accession:Q15418.2
UniProt Secondary Accession:Q15418,Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2, A6NGG4 A8K9K7, B2RDY8, B7Z5J0,
UniProt Related Accession:Q15418
Molecular Weight:72,698 Da
NCBI Full Name:Ribosomal protein S6 kinase alpha-1
NCBI Synonym Full Names:ribosomal protein S6 kinase, 90kDa, polypeptide 1
NCBI Official Symbol:RPS6KA1  
NCBI Official Synonym Symbols:RSK; HU-1; RSK1; p90Rsk; MAPKAPK1A  
NCBI Protein Information:ribosomal protein S6 kinase alpha-1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1; S6K-alpha 1; S6K-alpha-1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); p90-RSK 1; p90RSK1; p90S6K; ribosomal S6 kinase 1; ribosomal protein S6 kinase alpha 1
UniProt Protein Name:Ribosomal protein S6 kinase alpha-1
UniProt Synonym Protein Names:90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1; RSK-1
Protein Family:Ribosomal protein S6 kinase
UniProt Gene Name:RPS6KA1  
UniProt Entry Name:KS6A1_HUMAN

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