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Phospho-RPS6KA1/RPS6KA3/RPS6KA2/RPS6KA6 (S221/227/S218/232) Antibody (PACO04956)

SKU:
PACO04956
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Phospho-RPS6KA1/RPS6KA3/RPS6KA2/RPS6KA6 (S221/227/S218/232) Antibody (PACO04956)

The Phospho-RPS6KA1/RPS6KA3/RPS6KA2/RPS6KA6 (S221/227/S218/232) Antibody (PAC04956) is a crucial tool for researchers studying the phosphorylation of RPS6KA1, RPS6KA3, RPS6KA2, and RPS6KA6 proteins. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the phosphorylated sites S221/227/S218/232 on these proteins, this antibody allows for the detection and analysis of their activity in various cell types.The RPS6KA family of proteins are key regulators of cell growth and proliferation, making them important targets for study in cancer research and other related fields.

Phosphorylation at the S221/227/S218/232 sites is known to play a critical role in signaling pathways that control cell division and survival. By using this antibody to monitor the phosphorylation status of these proteins, researchers can gain valuable insights into the mechanisms underlying cell growth and development.Overall, the Phospho-RPS6KA1/RPS6KA3/RPS6KA2/RPS6KA6 (S221/227/S218/232) Antibody (PAC04956) is a valuable tool for investigating the functional significance of these proteins in various physiological and pathological processes. Its high specificity and sensitivity make it an ideal

Antibody Name:Phospho-RPS6KA1/RPS6KA3/RPS6KA2/RPS6KA6 (S221/227/S218/232) Antibody
Antibody SKU:PACO04956
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from human Rsk-1/2/3/4 around the phosphorylation site of S221/227/S218/232.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAP
UniProt Protein Function:p90RSK: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.
UniProt Protein Details:

Protein type:EC 2.7.11.1; Protein kinase, AGC; Kinase, protein; Translation; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; RSK subfamily

Chromosomal Location of Human Ortholog: 1p

Cellular Component: nucleoplasm; cytoplasm; spindle; cytosol; nucleus

Molecular Function:protein serine/threonine kinase activity; protein binding; caspase inhibitor activity; protein serine/threonine/tyrosine kinase activity; magnesium ion binding; ATP binding

Biological Process: regulation of transcription in response to stress; axon guidance; nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; regulation of translation in response to stress; toll-like receptor 3 signaling pathway; negative regulation of caspase activity; cell cycle; signal transduction; protein amino acid phosphorylation; positive regulation of cell growth; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; synaptic transmission; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; toll-like receptor 4 signaling pathway; negative regulation of apoptosis

NCBI Summary:This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q15418
NCBI GenInfo Identifier:20178306
NCBI Gene ID:6195
NCBI Accession:Q15418.2
UniProt Secondary Accession:Q15418,Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2, A6NGG4 A8K9K7, B2RDY8, B7Z5J0,
UniProt Related Accession:Q15418
Molecular Weight:72,698 Da
NCBI Full Name:Ribosomal protein S6 kinase alpha-1
NCBI Synonym Full Names:ribosomal protein S6 kinase, 90kDa, polypeptide 1
NCBI Official Symbol:RPS6KA1  
NCBI Official Synonym Symbols:RSK; HU-1; RSK1; p90Rsk; MAPKAPK1A  
NCBI Protein Information:ribosomal protein S6 kinase alpha-1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1; S6K-alpha 1; S6K-alpha-1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); p90-RSK 1; p90RSK1; p90S6K; ribosomal S6 kinase 1; ribosomal protein S6 kinase alpha 1
UniProt Protein Name:Ribosomal protein S6 kinase alpha-1
UniProt Synonym Protein Names:90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1; RSK-1
Protein Family:Ribosomal protein S6 kinase
UniProt Gene Name:RPS6KA1  
UniProt Entry Name:KS6A1_HUMAN

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