The Phospho-RET (Y905) Polyclonal Antibody (CABP0600) is a valuable tool for researchers studying the RET protein, a receptor tyrosine kinase involved in cell growth and differentiation. This antibody, produced in rabbits, exhibits high specificity towards human samples and is validated for use in Western blot applications. By targeting the phosphorylated Y905 site on the RET protein, this antibody enables precise detection and analysis in various cell types, making it an essential component for investigations in cancer biology and signal transduction pathways.
The RET protein plays a crucial role in cell signaling cascades, particularly in the development and progression of multiple cancers, including thyroid and lung cancer. Phosphorylation of the Y905 residue on RET is associated with activation of downstream signaling pathways that regulate cell proliferation and survival. Understanding the signaling mechanisms involving phosphorylated RET is essential for identifying potential therapeutic targets and developing novel treatments for cancer and other related diseases.
Product Name:
Phospho-Ret-Y905 Rabbit Polyclonal Antibody
SKU:
CABP0600
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around Y905 of human Ret (NP_066124.1).
Cell membrane, Endosome membrane, Single-pass type I membrane protein.
Calculated MW:
124kDa
Observed MW:
124kDa
This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.
Purification Method:
Affinity purification
Gene ID:
5979
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of K562 cells, using Phospho-Ret-Y905 antibody (CABP0600).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
