Phospho-RB-S780 Monoclonal Antibody (CABP1419)
- SKU:
- CABP1419
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
Product Name: | Phospho-RB-S780 Monoclonal Antibody |
SKU: | CABP1419 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S780 of Human RB. |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:2000 - 1:20000 |
Synonyms: | RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1; Phospho-RB-S780 |
Positive Sample: | HeLa+Calyculin A, C6+Calyculin A |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 106kDa |
Observed MW: | 110kDa |
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Purification Method: | Affinity purification |
Gene ID: | 5925 |
Clone Number: | ARC52461 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |